A Rare Case of Primary Cutaneous Ewing’s Sarcoma Diagnosed by Cytology Sampling: Case Report and Review of the Literature

Abstract

Ewing sarcoma (EWS) is an uncommon malignancy of the family of small blue round-cell tumors, with several known translocations involving EWSR1 and the ETS family transcription factors. EWS occurs in bone and soft tissue but rarely in skin. Radiological imaging and clinical presentation are not specific enough to conclude the diagnosis of extraskeletal cutaneous Ewing's sarcoma (CES). In a few small studies, there have been reports of better CES prognoses than other EWS types. Tissue sampling (tissue biopsy or aspiration cytology) and enough immunohistochemistry (IHC) and translocation molecular genetic studies must be done together to make a final diagnosis. We present a case of a 73-year-old female who presented with a cutaneous cheek lesion that was initially misdiagnosed as a benign adnexal tumor. IHC and cytogenetic tests eventually confirmed the tumor's diagnosis of CES after two recurrences. The definitive diagnosis was based solely on fine needle aspiration (FNA) material.

Keywords:

Ewing sarcoma, Cutaneous, Small blue round cells, Molecular, Translocation

Authors

  • Yasmine Chervin Ross University School of Medicine, Barbados
  • Yasmeen Abdulrazzak American University of the Caribbean Medical School, USA
  • Naomi Saint Jean Ross University School of Medicine, Barbados
  • Daniel Shenouda American University of the Caribbean Medical School, USA
  • Kaylee Watson Ross University School of Medicine, Barbados
  • Corey Steinman American University of the Caribbean Medical School, USA
  • Paul Bishay American University of the Caribbean Medical School, USA
  • Meena Alzamani American University of the Caribbean Medical School, USA
  • Anthony T Dean Jr American University of the Caribbean Medical School, USA
  • Jessica Jahoda Research Writing & Publication (RWP), LLC, NY, USA
  • Mohamed Aziz Research Writing & Publication (RWP), LLC, NY, USA

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Published

04/18/2024

Issue

Vol. 3 No. 1 (2024):

Section

Articles