Non-mucinous, Invasive Mixed Ductal Lobular Carcinoma with Metastatic Mucinous Features in Lymph Nodes and Overexpression of HER-2 and Estrogen: Case Report and Review of the Literature

Abstract

Invasive ductal carcinoma (IDC) and invasive lobular carcinoma (ILC) are the most common types of invasive breast carcinoma. However, there are several cases where both ductal and lobular characteristic features are present in the same tumor. These types of mixed tumors are referred to as invasive mixed ductal lobular carcinoma (mDLC). Mixed ductal lobular carcinoma represents a unique clinical entity that integrates certain attributes from both lobular and ductal breast carcinoma. Mucinous breast carcinoma is an uncommon type defined as pure mucinous carcinoma (PMC) when it shows at least 90% mucinous component and mixed mucinous carcinoma (MMC) when it shows less than 50% mucinous component. The categorization of invasive breast cancer into discrete subtypes based on tumor histology holds specific importance for diagnostic and prognostic considerations. This report details a case of invasive mixed ductal lobular carcinoma in a 42-year-old woman, notable for the absence of a mucinous component in the primary tumors. At the same time, two out of nine positive axillary lymph nodes exhibit characteristics consistent with mucinous carcinoma. We review the relevant literature and attempt to understand the mechanisms behind the phenomenon of the changing features of a metastatic tumor from the primary tumor.

Keywords:

Mixed ductal lobular breast carcinoma, Mucinous carcinoma, Lymph nodes metastasis, Primary carcinoma

Authors

  • Fadi Jamaleddin American University of the Caribbean Medical School, USA
  • Chantal Markarian American University of the Caribbean Medical School, USA
  • Fardowsa Robow St George University School of Medicine, Grenada, West Indies
  • Stephanie McCarthy American University of the Caribbean Medical School, USA
  • Melissa Candela American University of the Caribbean Medical School, USA
  • Andressa Balbi American University of the Caribbean Medical School, USA
  • Racquel Kaizer American University of the Caribbean Medical School, USA
  • Neda Sohrabi American University of the Caribbean Medical School, USA
  • Jessica Jahoda American University of the Caribbean Medical School, USA
  • Mohamed Aziz Research Writing & Publication (RWP) LLC, NY, USA.

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Published

01/02/2024

Issue

Vol. 3 No. 1 (2024):

Section

Articles