Solitary Trichoepithelioma of the Scrotum, an Uncommon Site of an Uncommon Tumor: Report of a Case with a Brief Literature Review

Abstract

Trichoepithelioma (TE) is a rare benign adnexal tumor developing from the hair follicle, which may occur as solitary or multiple lesions. Solitary trichoepithelioma (STE) is uncommon and presents a diagnostic dilemma, with its clinical and histopathologic features showing considerable overlap with other cutaneous neoplasms, including basal cell carcinoma (BCC). We present the case of a 71-year-old man with a slowly growing, focally ulcerated lesion on the right side of the scrotum skin. Histologic examination revealed distinctive nests of basaloid cells with keratin horn cysts and a fibrous cellular stroma consistent with STE. Immunohistochemistry (IHC) findings supported the diagnosis, and germline testing of CYLD was negative. This case underlines the importance of including TE in the differential diagnosis of adnexal neoplasms and reflects the significance of clinical knowledge to avoid misdiagnosis. We also present a short literature review of this uncommon tumor.

Keywords:

Trichoepithelioma, Solitary, Familial, Desmoplastic, Trichoblastic carcinoma, Basal cell carcinoma

Authors

  • Mariam Sobh American University of the Caribbean Medical School, USA
  • Amruth Alluri American University of the Caribbean Medical School, USA
  • Cecilia Alejandra Clendenes-Salazar Peruvian University of Applied Sciences, LIMA, Peru
  • Raffi Paulus American University of the Caribbean Medical School, USA
  • Leah Magdal American University of the Caribbean Medical School, USA
  • Isabella Seferoglou American University of the Caribbean Medical School, USA
  • Sharuk Noor Ali American University of the Caribbean Medical School, USA
  • Dalia Justo American University of the Caribbean Medical School, USA
  • Zahraa Sari Tishreen University, College of Medicine, Syria
  • Jessica Jahoda Research Writing & Publication (RWP), LLC, NY, USA
  • Mohamed Aziz Research Writing & Publication (RWP), LLC, NY, USA

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Published

04/04/2025

Issue

Vol. 5 No. 1 (2024):

Section

Articles